USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: CH60_HUMAN USC-OGP 2-DE database:  CH60_HUMAN CH60_HUMAN General information about the entry View entry in simple text format Entry name CH60_HUMAN Primary accession number P10809 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=60 kDa heat shock protein, mitochondrial; EC=3.6.4.9; AltName: Full=60 kDa chaperonin; AltName: Full=Chaperonin 60; Short=CPN60; AltName: Full=Heat shock protein 60; Short=HSP-60; Short=Hsp60; AltName: Full=HuCHA60; AltName: Full=Mitochondrial matrix protein P1; AltName: Full=P60 lymphocyte protein; Flags: Precursor;. Gene name Name=HSPD1 Synonyms=HSP60 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0332: pI=5.12; Mw=61844 SPOT OGP-0333: pI=5.18; Mw=61464 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0644: pI=5.20; Mw=61980 SPOT OGP-0645: pI=5.13; Mw=61618 SPOT OGP-0647: pI=5.17; Mw=60901 SPOT OGP-0649: pI=5.14; Mw=59143 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1129: pI=5.33; Mw=66847 SPOT OGP-1133: pI=5.37; Mw=64830 Cross-references UniProtKB/Swiss-Prot P10809; CH60_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name CH60_HUMAN Primary accession number P10809 Secondary accession number(s) B2R5M6 B7Z712 Q38L19 Q9UCR6 Sequence was last modified on  August 1, 1990 (version 2) Annotations were last modified on  March 15, 2017 (version 209) Name and origin of the protein Description RecName: Full=60 kDa heat shock protein, mitochondrial; EC=3.6.4.9; AltName: Full=60 kDa chaperonin; AltName: Full=Chaperonin 60; Short=CPN60; AltName: Full=Heat shock protein 60; Short=HSP-60; Short=Hsp60; AltName: Full=HuCHA60; AltName: Full=Mitochondrial matrix protein P1; AltName: Full=P60 lymphocyte protein; Flags: Precursor; Gene name Name=HSPD1 Synonyms=HSP60 Encoded on Name=HSPD1; Synonyms=HSP60 Keywords 3D-structure; Acetylation; Alternative splicing; ATP-binding; Chaperone; Complete proteome; Direct protein sequencing; Disease mutation; Hereditary spastic paraplegia; Host-virus interaction; Hydrolase; Leukodystrophy; Mitochondrion; Neurodegeneration; Nucleotide-binding; Phosphoprotein; Reference proteome; Transit peptide. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M22382; AAA60127.1; -; mRNA EMBL M34664; AAA36022.1; -; mRNA EMBL AJ250915; CAB75426.1; -; Genomic_DNA EMBL DQ217936; ABB01006.1; -; Genomic_DNA EMBL AK301276; BAH13448.1; -; mRNA EMBL AK312240; BAG35173.1; -; mRNA EMBL AC010746; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC020550; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC114809; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC002676; AAH02676.1; -; mRNA EMBL BC003030; AAH03030.1; -; mRNA EMBL BC067082; AAH67082.1; -; mRNA EMBL BC073746; AAH73746.1; -; mRNA CCDS CCDS33357.1; -. [P10809-1]; . PIR A32800; A32800; . RefSeq NP_002147.2; NM_002156.4. [P10809-1]; . RefSeq NP_955472.1; NM_199440.1. [P10809-1]; . UniGene Hs.595053; -; . UniGene Hs.727543; -; . PDB 4PJ1; X-ray; 3.15 A; A/B/C/D/E/F/G/H/I/J/K/L/M/N=27-556 PDBsum 4PJ1; -; . ProteinModelPortal P10809; -; . SMR P10809; -; . BioGrid 109561; 277; . DIP DIP-58N; -; . IntAct P10809; 117; . MINT MINT-1162735; -; . STRING 9606.ENSP00000340019; -; . ChEMBL CHEMBL4721; -; . iPTMnet P10809; -; . PhosphoSitePlus P10809; -; . SwissPalm P10809; -; . BioMuta HSPD1; -; . DMDM 129379; -; . DOSAC-COBS-2DPAGE P10809; -; . OGP P10809; -; . REPRODUCTION-2DPAGE IPI00784154; -; . REPRODUCTION-2DPAGE P10809; -; . SWISS-2DPAGE P10809; -; . UCD-2DPAGE P10809; -; . EPD P10809; -; . MaxQB P10809; -; . PaxDb P10809; -; . PeptideAtlas P10809; -; . PRIDE P10809; -; . TopDownProteomics P10809-1; -. [P10809-1]; . DNASU 3329; -; . Ensembl ENST00000345042; ENSP00000340019; ENSG00000144381. [P10809-1]; . Ensembl ENST00000388968; ENSP00000373620; ENSG00000144381. [P10809-1]; . GeneID 3329; -; . KEGG hsa:3329; -; . UCSC uc002uui.4; human. [P10809-1]; . CTD 3329; -; . DisGeNET 3329; -; . GeneCards HSPD1; -; . HGNC HGNC:5261; HSPD1; . HPA CAB002775; -; . HPA CAB072816; -; . HPA HPA001523; -; . HPA HPA050025; -; . MalaCards HSPD1; -; . MIM 118190; gene; . MIM 605280; phenotype; . MIM 612233; phenotype; . neXtProt NX_P10809; -; . OpenTargets ENSG00000144381; -; . Orphanet 100994; Autosomal dominant spastic paraplegia type 13; . Orphanet 280288; Pelizaeus-Merzbacher-like disease due to HSPD1 mutation; . PharmGKB PA29527; -; . eggNOG KOG0356; Eukaryota; . eggNOG COG0459; LUCA; . GeneTree ENSGT00390000005727; -; . HOGENOM HOG000076290; -; . HOVERGEN HBG001982; -; . InParanoid P10809; -; . KO K04077; -; . OMA KDPAMGG; -; . OrthoDB EOG091G04JM; -; . PhylomeDB P10809; -; . TreeFam TF300475; -; . Reactome R-HSA-1268020; Mitochondrial protein import; . Reactome R-HSA-8869496; TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation; . ChiTaRS HSPD1; human; . GeneWiki GroEL; -; . GenomeRNAi 3329; -; . PRO PR:P10809; -; . Proteomes UP000005640; Chromosome 2; . Bgee ENSG00000144381; -; . CleanEx HS_HSPD1; -; . ExpressionAtlas P10809; baseline and differential; . Genevisible P10809; HS; . GO GO:0009986; C:cell surface; IDA:UniProtKB; . GO GO:0005905; C:clathrin-coated pit; IDA:BHF-UCL; . GO GO:0030135; C:coated vesicle; IDA:BHF-UCL; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:UniProtKB; . GO GO:0005769; C:early endosome; IDA:BHF-UCL; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0005615; C:extracellular space; IDA:BHF-UCL; . GO GO:0046696; C:lipopolysaccharide receptor complex; IDA:BHF-UCL; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005743; C:mitochondrial inner membrane; ISS:BHF-UCL; . GO GO:0005759; C:mitochondrial matrix; TAS:BHF-UCL; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0043209; C:myelin sheath; IEA:Ensembl; . GO GO:0005886; C:plasma membrane; IEA:Ensembl; . GO GO:0043234; C:protein complex; IDA:UniProtKB; . GO GO:0030141; C:secretory granule; ISS:BHF-UCL; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0016887; F:ATPase activity; ISS:BHF-UCL; . GO GO:0051087; F:chaperone binding; IPI:UniProtKB; . GO GO:0003688; F:DNA replication origin binding; ISS:BHF-UCL; . GO GO:0003725; F:double-stranded RNA binding; IDA:MGI; . GO GO:0001530; F:lipopolysaccharide binding; IDA:BHF-UCL; . GO GO:0002039; F:p53 binding; IPI:UniProtKB; . GO GO:0044183; F:protein binding involved in protein folding; IBA:GO_Central; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0003697; F:single-stranded DNA binding; ISS:BHF-UCL; . GO GO:0031625; F:ubiquitin protein ligase binding; IPI:ParkinsonsUK-UCL; . GO GO:0051082; F:unfolded protein binding; IC:UniProtKB; . GO GO:0006458; P:'de novo' protein folding; ISS:BHF-UCL; . GO GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:BHF-UCL; . GO GO:0008637; P:apoptotic mitochondrial changes; IBA:GO_Central; . GO GO:0042113; P:B cell activation; IDA:BHF-UCL; . GO GO:0002368; P:B cell cytokine production; IDA:BHF-UCL; . GO GO:0042100; P:B cell proliferation; IDA:BHF-UCL; . GO GO:0051131; P:chaperone-mediated protein complex assembly; ISS:BHF-UCL; . GO GO:0061077; P:chaperone-mediated protein folding; IBA:GO_Central; . GO GO:0048291; P:isotype switching to IgG isotypes; IDA:BHF-UCL; . GO GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IDA:BHF-UCL; . GO GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB; . GO GO:0043065; P:positive regulation of apoptotic process; IMP:BHF-UCL; . GO GO:0032727; P:positive regulation of interferon-alpha production; IDA:BHF-UCL; . GO GO:0032729; P:positive regulation of interferon-gamma production; IDA:BHF-UCL; . GO GO:0032733; P:positive regulation of interleukin-10 production; IDA:BHF-UCL; . GO GO:0032735; P:positive regulation of interleukin-12 production; IDA:BHF-UCL; . GO GO:0032755; P:positive regulation of interleukin-6 production; IDA:BHF-UCL; . GO GO:0043032; P:positive regulation of macrophage activation; IDA:BHF-UCL; . GO GO:0050870; P:positive regulation of T cell activation; IDA:BHF-UCL; . GO GO:0002842; P:positive regulation of T cell mediated immune response to tumor cell; IDA:BHF-UCL; . GO GO:0045041; P:protein import into mitochondrial intermembrane space; IBA:GO_Central; . GO GO:0051604; P:protein maturation; ISS:BHF-UCL; . GO GO:0042026; P:protein refolding; IDA:UniProtKB; . GO GO:0050821; P:protein stabilization; IMP:UniProtKB; . GO GO:0006357; P:regulation of transcription from RNA polymerase II promoter; TAS:Reactome; . GO GO:0009409; P:response to cold; ISS:AgBase; . GO GO:0006986; P:response to unfolded protein; IDA:BHF-UCL; . GO GO:0042110; P:T cell activation; IDA:MGI; . GO GO:0016032; P:viral process; IEA:UniProtKB-KW; . Gene3D 1.10.560.10; -; 2; . Gene3D 3.50.7.10; -; 1; . HAMAP MF_00600; CH60; 1; . InterPro IPR018370; Chaperonin_Cpn60_CS; . InterPro IPR001844; Chaprnin_Cpn60; . InterPro IPR002423; Cpn60/TCP-1; . InterPro IPR027409; GroEL-like_apical_dom; . InterPro IPR027413; GROEL-like_equatorial; . Pfam PF00118; Cpn60_TCP1; 1; . PRINTS PR00298; CHAPERONIN60; . SUPFAM SSF52029; SSF52029; 1; . TIGRFAMs TIGR02348; GroEL; 1; . PROSITE PS00296; CHAPERONINS_CPN60; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

[Home]